关键词: 狼疮肾炎, 诊断 , 治疗, 管理 , 指南

Abstract: Since  the  first  edition  “ Chinese  guideline  for  the  diagnosis  and  treatment  of  lupus  nephritis”  was published in 2019， a  large  number  of  clinical  studies  have  been  conducted  in  the  diagnosis，  evaluation，  treatment，  and management of lupus nephritis both domestically and internationally， obtaining more new evidence⁃based evidence. In order to update  the  guideline，  a  multidisciplinary  guideline  working  group  was  established，  the  grading  of  recommendation assessment， development and  evaluation  （ GRADE）  system  was  used  to  rate  the  quality  of  evidence  and  the  strength  of recommendations. For  clinical  issues  without  sufficient  evidence⁃based  evidence，  practical  points  were  presented.  In  the updated 2025 Chinese practice  guideline  for  the  diagnosis，  treatment，  and  management  of  lupus  nephritis，  the  guideline expert group developed 20 recommendations and 25 practice points， intended to provide guidance for clinicians in making optimal treatment decisions and disease management. The complete version of the “2025 Chinese practice guideline for the diagnosis， treatment and management  of  lupus  nephritis”  has  been  published  in  the  Chinese  Medical  Journal.  To  further promote and  expand  the  dissemination  and  implementation  of  the  guidelines，  this  journal  has  released  the  executive summary of the “ Chinese practice guideline for the diagnosis， treatment and management of lupus nephritis”.

Key words: lupus nephritis ,  , diagnosis,  treatment, management , guideline